I think in a fight where someone has been boxing for 5 years and someone has been practicing karate for 5 years, the boxer would most likely win. In this situation I think it comes down to conditioning. Most karate practictioners are just average strength. Boxers are constantly getting tougher and stronger. They run, jump rope, lift weights and in great shape. They generally have great footwork and fast hands. Now where I think a karate practioner would win is when they are very experienced. People like my instructor who have 9th degree black belts. They have muscle memory and extrememly fast. On a boxer they would take out the lower legs and then move in fast to other areas on the body. A boxer can only get so good in boxing and then he gets older and cant lift the weights anymore. A karate practioner just keeps getting better.